111In-oxine platelet survivals in thrombocytopenic infants
نویسندگان
چکیده
منابع مشابه
‘ In - Oxine Platelet Survivals in Thrombocytopenic Infants
Thrombocytopenia is a common occurrence (20%) in sick neonates. but the causes have not been well studied. In this report we demonstrate that thrombocytopenia in the neonate is characterized by increased platelet destruction as shown by shortened homologous “In-oxine-labeled platelet life spans. Thirty-one prospectively studied thrombocytopenic neonates were investigated by measuring the “In-la...
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Abstract Objective Immune thrombocytopenic purpura (ITP) manifests as an easy bruising or extravasation of blood from capillaries into skin and mucous membranes. The characteristics of acute ITP in infants have rarely been described. In order to better understand acute ITP in infants, the characteristics of the disease at this age group was investigated. Material and Methods The present des...
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Platelet dynamics in chronic liver disease have been studied using 111Indium-8-hydroxyquinolone (111In-oxine) as a platelet label. In 20 patients, mainly with alcoholic cirrhosis, the platelet mean life span was reduced in 12 and the splenic platelet pool increased, often markedly so, in 15. However, the platelet count was not significantly related to mean bile span, the splenic platelet pool, ...
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Introduction: The field of stem cell biology and regenerative medicine is rapidly moving toward translation to clinical practice. Stem cell therapy seems to be a new treatment option for some diseases. So, tracking the distribution of stem cells is crucial to their therapeutic use. Based on this fact we labeled human mesenchymal stem cells (MSCs) with 111...
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We have studied the kinetics, biodistribution, and fate of autologous platelets labeled with 111In-oxine in rabbits. The initial recovery was 75% and mean survival time was 2.8 days when the data were analyzed by the multiple-hit gamma function model. Using a modified geometric mean for correction of attenuation, there was good correlation between the values obtained by in vivo quantification a...
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ژورنال
عنوان ژورنال: Blood
سال: 1987
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v70.3.652.bloodjournal703652